H2N2V1, Main, Exploration, bibRecord, 001384

Differential Polymerase Activity in Avian and Mammalian Cells Determines Host Range of Influenza Virus▿

Identifieur interne : 001384 ( Main/Exploration ); précédent : 001383; suivant : 001385

Differential Polymerase Activity in Avian and Mammalian Cells Determines Host Range of Influenza Virus▿

Auteurs : G. Gabriel [Allemagne] ; M. Abram [Allemagne] ; B. Keiner [Allemagne] ; R. Wagner [Allemagne] ; H.-D. Klenk [Allemagne] ; J. Stech [Allemagne]

Source :

Journal of Virology [ 0022-538X ] ; 2007.

RBID : PMC:1951401

Abstract

As recently shown, mutations in the polymerase genes causing increased polymerase activity in mammalian cells are responsible for the adaptation of the highly pathogenic avian influenza virus SC35 (H7N7) to mice (G. Gabriel et al., Proc. Natl. Acad. Sci. USA 102:18590-18595, 2005). We have now compared mRNA, cRNA, and viral RNA levels of SC35 and its mouse-adapted variant SC35M in avian and mammalian cells. The increase in levels of transcription and replication of SC35M in mammalian cells was linked to a decrease in avian cells. Thus, the efficiency of the viral polymerase is a determinant of both host specificity and pathogenicity.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1951401

DOI: 10.1128/JVI.00666-07
PubMed: 17567688
PubMed Central: 1951401

Affiliations:

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<front><div type="abstract" xml:lang="en"><p>As recently shown, mutations in the polymerase genes causing increased polymerase activity in mammalian cells are responsible for the adaptation of the highly pathogenic avian influenza virus SC35 (H7N7) to mice (G. Gabriel et al., Proc. Natl. Acad. Sci. USA 102:18590-18595, 2005). We have now compared mRNA, cRNA, and viral RNA levels of SC35 and its mouse-adapted variant SC35M in avian and mammalian cells. The increase in levels of transcription and replication of SC35M in mammalian cells was linked to a decrease in avian cells. Thus, the efficiency of the viral polymerase is a determinant of both host specificity and pathogenicity.</p>
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Differential Polymerase Activity in Avian and Mammalian Cells Determines Host Range of Influenza Virus▿

Differential Polymerase Activity in Avian and Mammalian Cells Determines Host Range of Influenza Virus▿

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